PREDECT Publications

  1. Establishment and Analysis of Tumor Slice Explants As a Prerequisite for Diagnostic Testing
    Nov. 2018 - published in JoVE

  2. Altered p53 functionality in cancer-associated fibroblasts contributes to their cancer supporting features
    June 2018 - published in PNAS

  3. 3D-3-culture: A tool to unveil macrophage plasticity in the tumour microenvironment
    May 2018 - published in Biomaterials

  4. Spatial aspects of oncogenic signalling determine the response to combination therapy in slice explants from Kras-driven lung tumours
    April 2018 - published in J Pathol

  5. Protocols and characterization data for 2D, 3D, and slice-based tumor models from the PREDECT project
    Nov. 2017 - published in Sci Data

  6. Systems pathology by multiplexed immunohistochemistry and whole-slide digital image analysis
    Nov. 2017 - published in Scientific Reports

  7. The Volume of Three-Dimensional Cultures of Cancer Cells InVitro Influences Transcriptional Profile Differences and Similarities with Monolayer Cultures and Xenografted Tumors
    Sept. 2017 - published in Neoplasia

  8. Cell of origin links histotype spectrum to immune microenvironment diversity in non-small cell lung cancer driven by mutant Kras and loss of Lkb1
    Jan. 2017 - published in Cell Reports

  9. Drug screening in 3D in vitro tumor models: overcoming current pitfalls of efficacy read-outs
    Dec. 2016 - published in Biotechnology Journal

  10. Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery
    July 2016 - published in Nature: Scientific Reports

  11. Ellipsoid Segmentation Model for Analyzing Light-Attenuated 3D Confocal Image Stacks of Fluorescent Multi-Cellular Spheroids
    June 2016 - published in PLOS One

  12. MET expression during prostate cancer progression
    April 2016 - published in Oncotarget

  13. Adaptable stirred-tank culture strategies for large scale production of multicellular spheroid-based tumor cell models
    March 2016 - published in J Biotechnol.

  14. A Preclinical Model for ERα-Positive Breast Cancer Points to the Epithelial Microenvironment as Determinant of Luminal Phenotype and Hormone Response
    March 2016 - published in Cancer Cell

  15. Modelling the tumour microenvironment in long-term microencapsulated 3D co-cultures recapitulates phenotypic features of disease progression.
    February 2016 - published in Biomaterials

  16. Characterization of Heterogeneous Prostate Tumors in Targeted Pten Knockout Mice.
    January 2016 - published in PLOS One

  17. Capturing complex tumour biology in vitro: histological and molecular characterisation of precision cut slices.
    December 2015 - published in Scientific Reports

  18. Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion
    July 2015 - published in Oncogene

  19. Par6G suppresses cell proliferation and is targeted by loss-of-function mutations in multiple cancers
    June 2015 - published in Oncogene

  20. ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component
    May 2015 - published in Nucleic Acids Research

  21. High EMT Signature Score of Invasive Non- Small Cell Lung Cancer (NSCLC) Cells Correlates with NFκB Driven Colony- Stimulating Factor 2 (CSF2/GM-CSF) Secretion by Neighboring Stromal Fibroblasts
    April 2015 - published in PLOS One

  22. An ex vivo model to study hormone action in the human breast
    January 2015 - published in JoVE

  23. Three-dimensional models of cancer for pharmacology and cancer cell biology: Capturing tumor complexity in vitro/ex vivo
    September 2014 - published in Biotechnology Journal

  24. Organotypic tissue cultures: a useful platform for evaluation of drug response in the intact tumour environment?
    September 2013 - Oral presentation at the DDResponse project Workshop on 3D culture models for radiation and cancer research, Rotterdam, Netherlands

  25. PREDECT developing advanced, complex in vitro 3D models for cancer target validation
    September 2013 - Oral presentation at the DDResponse project Workshop on 3D culture models for radiation and cancer research, Rotterdam, Netherlands

  26. Development of a Tissue Slice Culture Model for Prostate Cancer
    September 2013 - Oral presentation at the DDResponse project Workshop on 3D culture models for radiation and cancer research, Rotterdam, Netherlands

  27. Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis
    April 2013 - Publication in Proceedings of the National Academy of Sciences

  28. Progesterone/RANKL Is a Major Regulatory Axis in the Human Breast
    Schmid, et al. Manuscript published in Cancer Research

  29. Cancer cells cue the p53 response of cancer-associated fibroblasts to cisplatin
    June 2013 - Poster at the PCTRE, Malmö, Sweden

  30. Humanised in vitro co-culture demonstrates CRPC growth depends on adrenal androgens
    June 2013 - Poster at the PCTRE, Malmö, Sweden

  31. Establishment of a tissue-slice culture model for prostate cancer
  32. June 2013 - Poster at the PCTRE, Malmö, Sweden

  33. Establishment of a bioluminescent/fluorescent prostate cancer metastasis xenograft model
    June 2013 - Poster at the PCTRE, Malmö, Sweden

  34. Generation of 3D models that more faithfully represent prostate cancer tumour complexity
    June 2013 - Poster at the PCTRE, Malmö, Sweden

  35. Novel complex models for cancer target validation. What is the project (and why?) & key progress to date
  36. June 2013 - Oral presentation at the IMI Patient Focus Meeting, Brussels, Belgium

  37. Driving drugs to trial
    April 2013 - Interview in International Innovation

  38. Tumor growth characteristics of non-small cell lung cancer model LXFA 923 in humanized NSG mice
    April 2013 - Poster at the Oncotest symposium

  39. Progesterone/RANKL is a major regulatory axis in the human breast
    April 2013 - Publication in Science Translational Medicine

  40. Dual activity of abiraterone: CYP17 mediated androgen ablation and direct AR inhibition
    April 2013 - Poster at the AACR annual meeting, Washington, DC, USA

  41. Abiraterone is able to block AR activation induced by accumulating precursor hormones resulting from CYP17A1 inhibition
    March 2013 - Poster at the 28th annual EAU Congress, Milan, Italy

  42. Establishment and characterization of novel PSA-Cre;PtenLoxp/LoxP mouse prostate cancer models
    February-March 2013 - Poster at the Keystone meeting: PI3-Kinase and Interplay with other signaling pathways, Keystone, Colorado, USA

  43. Patient derived models for Breast Cancer
    January 2013 - Oral presentation at the Tumour Model meeting, London, UK

  44. Tissue Slice Culture: An ex-vivo tumour culture platform for pharmacodynamic analysis and dose response readouts
    November 2012 - Poster at the meeting Preclinical in vivo models to interrogate cancer biology, biomarkers and therapeutic response - Joint BACR/Oncology Section, Royal Society of Medicine

  45. The IMI PREDECT project: novel in vitro platforms for target validation
    November 2012 - Presentation at the 24th EORTC-NCI-AACR Symposium on ‘Molecular Targets and Cancer Therapeutics’, Dublin

  46. Establishment of a bioluminescent prostate cancer metastasis xenograft model
    October 2012 - Poster at the 20th ESUR (EAU Section of Urological Research) meeting, Strasbourg

  47. Establishment of a tissue‐slice culture model for prostate cancer
    October 2012 - Poster at the 20th ESUR (EAU Section of Urological Research) meeting, Strasbourg

  48. Creating Biomedical R&D leadership for Europe to benefit patients and society
    September 2012 - Presentation at the Oncology Cross Project Meeting at IMI, Brussels

  49. PREDECT – novel complex models for cancer target validation
    September 2012 - Poster at the QuiCConcept General meeting, Brussels

  50. Cancer cells cue the p53 response of cancer-associated fibroblasts (CAFs) to cisplatin
    September 2012 - Publication in Cancer Research

  51. Tissue Slice Culture of Breast Tumours
    May 2012 - Presentation at the FP7 DDR (DNA Damage Response) workshop, Rotterdam

  52. PREDECT: a large Industry-Academic Collaboration to Improve Target Validation Platforms
    March 2012 - Presentation at the Informa Life Science's Oncology Drug Discovery conference 2012, Berlin, Germany

  53. Molecular Characterization of the Tumour-Stroma Crosstalk Using a Novel 3D Co-Culture In Vitro Model
    March 2012 - Poster at the conference 3D Cell Culture Advanced Model Systems, Applications & Enabling Technologies

  54. in vitro co-culture model shows adrenal cells can drive prostate cancer growth in androgen deprived conditions
    February 2012 - Poster at the 16th Molecular Medicine Day Rotterdam, The Netherlands

  55. Establishment of a tissue-slice culture model for prostate cancer
    February 2012 - Poster at the 16th Molecular Medicine Day Rotterdam, The Netherlands

  56. Why Do Anticancer Drugs Fail in the Clinic
    February 2012 - Presentation in Cambridge

  57. Making a Public-Private Partnership
    January 2012 - Tekes interview, Helsinki

  58. Development of more predictive models - IMI perspectives
    September 2011 - Presentation at the Tekes event, Finland

  59. PREDECT: a new public-private IMI partnership to build cancer target validation models
    September 2011 - Poster at the Finnish Biotech partnering event, Finland

  60. PREDECT: a powerful new European Consortium addressing novel laboratory models for cancer target validation
    2011 - Press release

  61. PREDECT - New Models for Preclinical Evaluation of Drug Efficacy in Common Solid Tumours
    April 2011 - Factsheet in IMI newsletter

  62. Innovative Medicines Initiative EU consortium ‘PREDECT’ is seeking ambitious Postdoctoral Fellows
    March 2011 - Recruitment Ad in Nature

  63. Innovative Medicines Initiative EU consortium ‘PREDECT’ is seeking ambitious Postdoctoral Fellows
    March 2011 - Recruitment Ad in Nature Reviews of Cancer